Memorial Sloane Kettering’s, Dr. Douglas Levine, and his team of researchers, have identified a genetic mutation that appears to play a key role in causing the rare and aggressive form of ovarian cancer: Small Cell Carcinoma of the Ovary–Hypercalcemic Type (SCCOHT). Dr. Levine and his team identified the SMARCA4 mutation as a contributing factor in promoting or blocking cancer growth in this rare tumor. “I don’t know of many cancers where there’s one gene that is universally mutated and seems to be driving the disease,” says Levine. His findings are reported online in the journal Nature Genetics. For more information, read the article Aggressive Ovarian Cancer May Be Caused by a Single Gene Mutation by Jim Stallard.